prednisone

PRED-ni-sone

Commonly used brand name(s)

In the U.S.

• Deltasone


• Prednicot


• Prednisone Intensol


• Sterapred


• Sterapred DS

Available Dosage Forms:

• Tablet


• Syrup


• Solution

Therapeutic Class: Endocrine-Metabolic Agent

Pharmacologic Class: Adrenal Glucocorticoid

Uses For prednisone

Prednisone provides relief for inflamed areas of the body. It is used to treat a number of different conditions, such as inflammation (swelling), severe allergies, adrenal problems, arthritis, asthma, blood or bone marrow problems, eye or vision problems, lupus, skin conditions, kidney problems, ulcerative colitis, and flare-ups of multiple sclerosis. Prednisone is a corticosteroid (cortisone-like medicine or steroid). It works on the immune system to help relieve swelling, redness, itching, and allergic reactions.

prednisone is available only with your doctor's prescription.

Before Using prednisone

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For prednisone, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to prednisone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of prednisone in children. However, pediatric patients are more likely to have slower growth and bone problems if prednisone is used for a long time. Recommended doses should not be exceeded, and the patient should be carefully monitored during therapy.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of prednisone in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for elderly patients receiving prednisone.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking prednisone, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using prednisone with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Rotavirus Vaccine, Live

Using prednisone with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Aldesleukin


• Asparaginase


• Bupropion


• Gatifloxacin


• Quetiapine


• Telaprevir

Using prednisone with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alatrofloxacin


• Alcuronium


• Alfalfa


• Amobarbital


• Aprobarbital


• Aspirin


• Atracurium


• Balofloxacin


• Butabarbital


• Butalbital


• Cinoxacin


• Ciprofloxacin


• Clarithromycin


• Clinafloxacin


• Enoxacin


• Fleroxacin


• Fluconazole


• Flumequine


• Fosphenytoin


• Gallamine


• Gemifloxacin


• Grepafloxacin


• Hexafluorenium


• Itraconazole


• Ketoconazole


• Levofloxacin


• Licorice


• Lomefloxacin


• Mephobarbital


• Metocurine


• Montelukast


• Moxifloxacin


• Norfloxacin


• Ofloxacin


• Pancuronium


• Pefloxacin


• Phenobarbital


• Phenytoin


• Primidone


• Prulifloxacin


• Rifampin


• Rifapentine


• Ritonavir


• Rosoxacin


• Rufloxacin


• Saiboku-To


• Secobarbital


• Sparfloxacin


• Temafloxacin


• Tosufloxacin


• Trovafloxacin Mesylate


• Vecuronium


• Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of prednisone. Make sure you tell your doctor if you have any other medical problems, especially:

• Cataracts or


• Congestive heart failure or


• Cushing's syndrome (adrenal gland problem) or


• Diabetes or


• Eye infection or


• Glaucoma or


• Hyperglycemia (high blood sugar) or


• Hypertension (high blood pressure) or


• Infection (e.g., bacterial, virus, or fungus) or


• Mood changes, including depression or


• Myasthenia gravis (severe muscle weakness) or


• Osteoporosis (weak bones) or


• Peptic ulcer, active or history of or


• Personality changes or


• Stomach or intestinal problems (e.g., diverticulitis, ulcerative colitis) or


• Tuberculosis, inactive—Use with caution. May make these conditions worse.

• Fungal infections or


• Herpes simplex eye infection—Should not be used in patients with these conditions.

Proper Use of prednisone

Take prednisone exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance for unwanted effects.

Take prednisone with food or milk to avoid stomach irritation.

Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.

Prednisone Intensol™ solution is a concentrated liquid. Measure the concentrated liquid with the special oral dropper that comes with the package.

If you use prednisone for a long time, do not suddenly stop using it without checking first with your doctor. You may need to slowly decrease your dose before stopping it completely.

Dosing

The dose of prednisone will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of prednisone. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage forms (concentrated solution, solution, and tablets):
  
  • Dose depends on medical condition:
    
    • Adults—At first, 5 to 60 milligrams (mg) per day. Your doctor may adjust your dose as needed.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of prednisone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Throw away any unused Prednisone Intensol™ solution 90 days after the bottle is opened for the first time.

Precautions While Using prednisone

If you will be taking prednisone for a long time, it is very important that your doctor check you at regular visits for any unwanted effects that may be caused by prednisone. Blood or urine tests may be needed to check for unwanted effects.

Using prednisone while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using prednisone, tell your doctor right away.

If you are using prednisone for a long time, tell your doctor about any extra stress or anxiety in your life, including other health concerns and emotional stress. Your dose of prednisone might need to be changed for a short time while you have extra stress.

Using too much of prednisone or using it for a long time may increase your risk of having adrenal gland problems. Talk to your doctor right away if you have more than one of these symptoms while you are using prednisone: blurred vision; dizziness or fainting; a fast, irregular, or pounding heartbeat; increased thirst or urination; irritability; or unusual tiredness or weakness.

prednisone may cause you to get more infections than usual. Avoid people who are sick or have infections and wash your hands often. If you are exposed to chickenpox or measles, tell your doctor right away. If you start to have a fever, chills, sore throat, or any other sign of an infection, call your doctor right away.

Check with your doctor right away if blurred vision, difficulty in reading, eye pain, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

While you are being treated with prednisone, do not have any immunizations (vaccines) without your doctor's approval. Prednisone may lower your body's resistance and the vaccine may not work as well or you might get the infection the vaccine is meant to prevent. In addition, you should not be around other persons living in your household who receive live virus vaccines because there is a chance they could pass the virus on to you. Some examples of live vaccines include measles, mumps, influenza (nasal flu vaccine), poliovirus (oral form), rotavirus, and rubella. Do not get close to them and do not stay in the same room with them for very long. If you have questions about this, talk to your doctor.

prednisone may cause changes in mood or behavior for some patients. Tell your doctor right away if you have depression; mood swings; a false or unusual sense of well-being; trouble with sleeping; or personality changes while taking prednisone.

prednisone might cause thinning of the bones (osteoporosis) or slow growth in children if used for a long time. Tell your doctor if you have any bone pain or if you have an increased risk for osteoporosis. If your child is using prednisone, tell the doctor if you think your child is not growing properly.

Make sure any doctor or dentist who treats you knows that you are using prednisone. prednisone may affect the results of certain skin tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

prednisone Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Aggression


• agitation


• anxiety


• blurred vision


• decrease in the amount of urine


• dizziness


• fast, slow, pounding, or irregular heartbeat or pulse


• headache


• irritability


• mental depression


• mood changes


• nervousness


• noisy, rattling breathing


• numbness or tingling in the arms or legs


• pounding in the ears


• shortness of breath


• swelling of the fingers, hands, feet, or lower legs


• trouble thinking, speaking, or walking


• troubled breathing at rest


• weight gain

Incidence not known

• Abdominal cramping and/or burning (severe)


• abdominal pain


• backache


• bloody, black, or tarry stools


• cough or hoarseness


• darkening of skin


• decrease in height


• decreased vision


• diarrhea


• dry mouth


• eye pain


• eye tearing


• facial hair growth in females


• fainting


• fatigue


• fever or chills


• flushed, dry skin


• fractures


• fruit-like breath odor


• full or round face, neck, or trunk


• heartburn and/or indigestion (severe and continuous)


• increased hunger


• increased thirst


• increased urination


• loss of appetite


• loss of sexual desire or ability


• lower back or side pain


• menstrual irregularities


• muscle pain or tenderness


• muscle wasting or weakness


• nausea


• pain in back, ribs, arms, or legs


• painful or difficult urination


• skin rash


• sleeplessness


• sweating


• trouble healing


• trouble sleeping


• unexplained weight loss


• unusual tiredness or weakness


• vision changes


• vomiting


• vomiting of material that looks like coffee grounds

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Increased appetite

Incidence not known

• Abnormal fat deposits on the face, neck, and trunk


• acne


• dry scalp


• lightening of normal skin color


• red face


• reddish purple lines on the arms, face, legs, trunk, or groin


• swelling of the stomach area


• thinning of the scalp hair

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Prednisolone/Sulfacetamide Ointment

Pronunciation: pred-NISS-oh-lone/sul-fa-SEE-ta-mide
Generic Name: Prednisolone/Sulfacetamide
Brand Name: Blephamide S.O.P.

Prednisolone/Sulfacetamide Ointment is used for:

Treating inflammation (swelling, warmth, redness, pain) of the eyes and eyelids when infection or risk of infection is present.

Prednisolone/Sulfacetamide Ointment is an antibacterial and corticosteroid combination. It works by reducing the itching, redness, and swelling of the eye. It also works to stop the growth of certain bacteria that cause eye infections.

Do NOT use Prednisolone/Sulfacetamide Ointment if:

• you are allergic to any ingredient in Prednisolone/Sulfacetamide Ointment, to other corticosteroids (eg, dexamethasone), or to other sulfonamides (eg, acetazolamide, celecoxib, hydrochlorothiazide, glyburide, probenecid, sulfamethoxazole, valdecoxib, zonisamide)


• you have a viral eye infection (eg, herpes simplex, vaccinia, chickenpox), tuberculosis eye infection, or fungal infection of the eye or eye structures


• you have thinning of the cornea of the eye

Contact your doctor or health care provider right away if any of these apply to you.

Before using Prednisolone/Sulfacetamide Ointment:

Some medical conditions may interact with Prednisolone/Sulfacetamide Ointment. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have thinning of the eye tissues (eg, cornea, sclera), other eye problems (eg, glaucoma, cataracts, nerve damage), severe dry eyes, or diabetes


• if you have recently had cataract surgery

Some MEDICINES MAY INTERACT with Prednisolone/Sulfacetamide Ointment. Tell your health care provider if you are taking any other medicine, especially any of the following:

• Silver-containing medicines (eg, silver nitrate) because the risk of side effects may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Prednisolone/Sulfacetamide Ointment may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Prednisolone/Sulfacetamide Ointment:

Use Prednisolone/Sulfacetamide Ointment as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Prednisolone/Sulfacetamide Ointment may be used around the eye or in the eye. To use Prednisolone/Sulfacetamide Ointment in the eye, first, wash your hands. Using your index finger, pull the lower eyelid away from your eye to form a pouch. Squeeze a thin strip of ointment into the pouch. After using Prednisolone/Sulfacetamide Ointment, gently close your eyes for 1 to 2 minutes. Wash your hands to remove any medicine that may be on them. Wipe the applicator tip with a clean, dry tissue.


• To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.


• To clear up your infection completely, use Prednisolone/Sulfacetamide Ointment for the full course of treatment. Keep using it even if you feel better in a few days.


• Do not use Prednisolone/Sulfacetamide Ointment if it is dark brown or has darkened since you began using it. Contact your doctor or pharmacist if you have questions about whether you should use Prednisolone/Sulfacetamide Ointment.


• Do not wear contact lenses while you are using Prednisolone/Sulfacetamide Ointment. Take care of your contact lenses as directed by the manufacturer. Check with your doctor before you use them.


• If you miss a dose of Prednisolone/Sulfacetamide Ointment, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Prednisolone/Sulfacetamide Ointment.

Important safety information:

• Prednisolone/Sulfacetamide Ointment may cause blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Prednisolone/Sulfacetamide Ointment with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• If your symptoms do not get better within 2 days or if they get worse, check with your doctor.


• Be sure to use Prednisolone/Sulfacetamide Ointment for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.


• Long-term or repeated use of Prednisolone/Sulfacetamide Ointment may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.


• Tell your doctor or dentist that you take Prednisolone/Sulfacetamide Ointment before you receive any medical or dental care, emergency care, or surgery.


• Do not use Prednisolone/Sulfacetamide Ointment for future eye problems unless directed by your doctor.


• Lab tests, including eye pressure, may be performed while you use Prednisolone/Sulfacetamide Ointment. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Prednisolone/Sulfacetamide Ointment should be used with extreme caution in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Prednisolone/Sulfacetamide Ointment while you are pregnant. It is not known if Prednisolone/Sulfacetamide Ointment is found in breast milk. Do not breast-feed while using Prednisolone/Sulfacetamide Ointment.

Possible side effects of Prednisolone/Sulfacetamide Ointment:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Temporary burning or stinging.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in vision; eye pain, itching, redness, swelling, irritation, or sores not present when you began using Prednisolone/Sulfacetamide Ointment; fever, chills, or sore throat; red, swollen, or blistered skin; severe or persistent blurred vision; unusual tiredness or weakness; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Prednisolone/Sulfacetamide side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Prednisolone/Sulfacetamide Ointment:

Store Prednisolone/Sulfacetamide Ointment at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Do not freeze. Store away from heat and light. Keep Prednisolone/Sulfacetamide Ointment out of the reach of children and away from pets.

General information:

• If you have any questions about Prednisolone/Sulfacetamide Ointment, please talk with your doctor, pharmacist, or other health care provider.


• Prednisolone/Sulfacetamide Ointment is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Prednisolone/Sulfacetamide Ointment. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Prednisolone/Sulfacetamide resources

• Prednisolone/Sulfacetamide Side Effects (in more detail)
• Prednisolone/Sulfacetamide Dosage
• Prednisolone/Sulfacetamide Use in Pregnancy & Breastfeeding
• Prednisolone/Sulfacetamide Drug Interactions
• Prednisolone/Sulfacetamide Support Group
• 1 Review for Prednisolone/Sulfacetamide - Add your own review/rating

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Pred-Ject-50

Generic Name: prednisolone (pred NIS oh lone)

Brand Names: Bubbli-Pred, Flo-Pred, Hydeltrasol, Key-Pred SP, Millipred, Orapred, Orapred ODT, Pediapred, Pred-Ject-50, Predacort 50, Predalone 50, Predate-50, Veripred 20

What is Pred-Ject-50 (prednisolone)?

Prednisolone is in a class of drugs called steroids. Prednisolone prevents the release of substances in the body that cause inflammation.

Prednisolone is used to treat many different conditions such as allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, or breathing disorders.

Prednisolone may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Pred-Ject-50 (prednisolone)?

You should not use this medication if you are allergic to prednisolone, or if you have a fungal infection anywhere in your body.

Before taking prednisolone, tell your doctor about all of your medical conditions, and about all other medicines you are using. There are many other diseases that can be affected by steroid use, and many other medicines that can interact with steroids.

Your steroid medication needs may change if you have any unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you during treatment.

Steroid medication can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. Tell your doctor about any illness or infection you have had within the past several weeks.

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using steroid medication.

Do not receive a "live" vaccine while you are taking prednisolone. Vaccines may not work as well while you are taking a steroid.

Do not stop using prednisolone suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication. Carry an ID card or wear a medical alert bracelet stating that you are taking a steroid, in case of emergency.

What should I discuss with my healthcare provider before taking Pred-Ject-50 (prednisolone)?

You should not use this medication if you are allergic to prednisolone, or if you have a fungal infection anywhere in your body.

Steroid medication can weaken your immune system, making it easier for you to get an infection. Steroids can also worsen an infection you already have, or reactivate an infection you recently had. Before taking this medication, tell your doctor about any illness or infection you have had within the past several weeks.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:

• 
  

  liver disease (such as cirrhosis);

  
  


• 
  

  kidney disease;

  
  


• 
  

  a thyroid disorder;

  
  


• 
  

  diabetes;

  
  


• 
  

  a history of malaria;

  
  


• 
  

  tuberculosis;

  
  


• 
  

  osteoporosis;

  
  


• 
  

  a muscle disorder such as myasthenia gravis;

  
  


• 
  

  glaucoma or cataracts;

  
  


• 
  

  herpes infection of the eyes;

  
  


• 
  

  stomach ulcers, ulcerative colitis, or diverticulitis;

  
  


• 
  

  depression or mental illness;

  
  


• 
  

  congestive heart failure; or

  
  


• 
  

  high blood pressure

  
  

FDA pregnancy category C. It is not known whether prednisolone is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. Prednisolone can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Steroids can affect growth in children. Talk with your doctor if you think your child is not growing at a normal rate while using this medication.

How should I take Pred-Ject-50 (prednisolone)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Your steroid medication needs may change if you have unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you.

Measure the liquid form of prednisolone with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Keep the disintegrating tablet (Orapred ODT) in its blister pack until you are ready to take the medicine. Open the package using dry hands, and peel back the foil from the tablet blister (do not push the tablet through the foil). Remove the tablet and place it in your mouth.

Allow the disintegrating tablet to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

Steroids can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using prednisolone.

Do not stop using prednisolone suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication. Carry an ID card or wear a medical alert bracelet stating that you are taking a steroid, in case of emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are taking steroid medication. Store prednisolone at room temperature away from moisture and heat.

What happens if I miss a dose?

If you miss a dose or forget to take your medicine, contact your doctor or pharmacist for instructions.

What happens if I overdose?

Seek emergency medical attention if you think you have received too much of this medicine.

A single large dose of prednisolone is not expected to produce life-threatening symptoms. However, long-term use of high steroid doses can lead to symptoms such as thinning skin, easy bruising, changes in the shape or location of body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

What should I avoid while taking Pred-Ject-50 (prednisolone)?

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using steroid medication.

Do not receive a "live" vaccine while you are being treated with prednisolone. Vaccines may not work as well while you are taking a steroid.

Avoid drinking alcohol while you are taking prednisolone.

Pred-Ject-50 (prednisolone) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• 
  

  problems with your vision;

  
  


• 
  

  swelling, rapid weight gain, feeling short of breath;

  
  


• 
  

  severe depression, unusual thoughts or behavior, seizure (convulsions);

  
  


• 
  

  bloody or tarry stools, coughing up blood;

  
  


• 
  

  pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate);

  
  


• 
  

  low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling); or

  
  


• 
  

  dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

  
  

Less serious side effects may include:

• 
  

  sleep problems (insomnia), mood changes;

  
  


• 
  

  acne, dry skin, thinning skin, bruising or discoloration;

  
  


• 
  

  slow wound healing;

  
  


• 
  

  increased sweating;

  
  


• 
  

  headache, dizziness, spinning sensation;

  
  


• 
  

  nausea, stomach pain, bloating; or

  
  


• 
  

  changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Pred-Ject-50 (prednisolone)?

There are many other medicines that can interact with steroids. Below is only a partial list of these medicines:

• 
  

  aspirin (taken on a daily basis or at high doses);

  
  


• 
  

  a diuretic (water pill);

  
  


• 
  

  a blood thinner such as warfarin (Coumadin);

  
  


• 
  

  cyclosporine (Gengraf, Neoral, Sandimmune);

  
  


• 
  

  insulin or diabetes medications you take by mouth;

  
  


• 
  

  ketoconazole (Nizoral);

  
  


• 
  

  rifampin (Rifadin, Rifater, Rifamate, Rimactane); or

  
  


• 
  

  seizure medications such as phenytoin (Dilantin) or phenobarbital (Luminal, Solfoton).

  
  

This list is not complete and there may be other drugs that can interact with prednisolone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More Pred-Ject-50 resources

• Pred-Ject-50 Side Effects (in more detail)
• Pred-Ject-50 Use in Pregnancy & Breastfeeding
• Pred-Ject-50 Drug Interactions
• Pred-Ject-50 Support Group
• 0 Reviews for Pred-Ject-50 - Add your own review/rating

• Bubbli-Pred Advanced Consumer (Micromedex) - Includes Dosage Information


• Flo-Pred Prescribing Information (FDA)


• Flo-Pred Consumer Overview


• Flo-Pred Suspension MedFacts Consumer Leaflet (Wolters Kluwer)


• Millipred Prescribing Information (FDA)


• Millipred DP MedFacts Consumer Leaflet (Wolters Kluwer)


• Orapred Solution MedFacts Consumer Leaflet (Wolters Kluwer)


• Orapred Prescribing Information (FDA)


• Orapred Consumer Overview


• Orapred ODT Prescribing Information (FDA)


• Orapred ODT MedFacts Consumer Leaflet (Wolters Kluwer)


• PediaPred Liquid MedFacts Consumer Leaflet (Wolters Kluwer)


• Prednisolone tablets Prescribing Information (FDA)


• Prednisolone Monograph (AHFS DI)


• Prednisolone MedFacts Consumer Leaflet (Wolters Kluwer)


• Prednisolone Professional Patient Advice (Wolters Kluwer)


• Prednisolone Acetate eent Monograph (AHFS DI)


• Prelone Syrup MedFacts Consumer Leaflet (Wolters Kluwer)


• Veripred 20 Prescribing Information (FDA)

Compare Pred-Ject-50 with other medications

• Asthma, acute
• Bronchopulmonary Dysplasia
• Bullous Pemphigoid
• Dermatitis
• Immunosuppression
• Inflammatory Conditions
• Multiple Sclerosis
• Nephrotic Syndrome
• Pemphigoid
• Pemphigus

Where can I get more information?

• Your pharmacist can provide more information about prednisolone.

See also: Pred-Ject-50 side effects (in more detail)

Pulmolite

Generic Name: technetium tc 99m albumin aggregated (Intravenous route)

tek-NEE-shee-um Tc 99m al-BUE-min AG-re-gay-ted

Commonly used brand name(s)

In the U.S.

• MPI MAA


• Pulmolite


• Technescan MAA

Available Dosage Forms:

• Kit

Therapeutic Class: Diagnostic Agent, Radiopharmaceutical Imaging

Uses For Pulmolite

Technetium Tc 99m albumin aggregated injection is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents, which may be used to find and treat certain diseases or to study the function of the body's organs.

Technetium Tc 99m albumin aggregated injection is used to help your doctor see an image of your lungs to help evaluate lung problems in children and adults. It is also used to help your doctor see an image of your peritoneovenous [LeVeen] shunt.

This medicine is to be given only by or under the direct supervision of a doctor with specialized training in nuclear medicine.

Before Using Pulmolite

In deciding to use a diagnostic test, any risks of the test must be weighed against the good it will do. This is a decision you and your doctor will make. Also, other things may affect test results. For this test, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of Technetium Tc 99m albumin aggregated injection in children.

Geriatric

No information is available on the relationship of age to the effects of technetium Tc 99m albumin aggregated injection in geriatric patients.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this diagnostic test. Make sure you tell your doctor if you have any other medical problems, especially:

• Allergy to human serum albumin, history of or


• Pulmonary hypertension (increased blood pressure in the lungs), severe—Should not be used in patients with these conditions.

• Blood circulation problems or


• Cor pulmonale (serious heart condition)—Use with caution. May make these conditions worse.

• Heart problems (e.g., right-to-left heart shunts)—It is not known if this medicine is safe in patients with this condition.

Proper Use of technetium tc 99m albumin aggregated

This section provides information on the proper use of a number of products that contain technetium tc 99m albumin aggregated. It may not be specific to Pulmolite. Please read with care.

A doctor or other trained health professional will give you or your child this medicine. This medicine is given through a needle placed in one of your veins before you have a scan.

Precautions While Using Pulmolite

It is very important that your doctor check you or your child closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to use it.

While using this medicine, you or your child may be exposed to radiation. Talk with your doctor if you have concerns about this.

Pulmolite Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Incidence not known

• Confusion


• faintness


• fever and chills


• skin rash or itching


• wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

pheniramine/pyrilamine/phenylpropanolamine

Generic Name: pheniramine/pyrilamine/phenylpropanolamine (fen IR a meen/pie RILL a meen/fen ill proe pa NOLE a meen)

Brand Names: Liqui-Minic Infant, Triactin, Triaminic Infant, Triaminic Pediatric

What is pheniramine/pyrilamine/phenylpropanolamine?

Pheniramine and pyrilamine are antihistamines. They block the effects of the naturally occurring chemical histamine in the body. Pheniramine and pyrilamine prevent sneezing; itchy, watery eyes and nose; and other symptoms of allergies and hay fever.

Phenylpropanolamine is a decongestant. It constricts (shrinks) blood vessels (veins and arteries). This reduces the blood flow to certain areas and allows nasal and respiratory (breathing) passages to open up.

Pheniramine/pyrilamine/phenylpropanolamine is used to treat nasal congestion and sinusitis (inflammation of the sinuses) associated with allergies, hay fever, and the common cold.

Phenylpropanolamine, an ingredient in this product, has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food and Drug Administration (FDA) recommends that consumers not use any products that contain phenylpropanolamine.

Pheniramine/pyrilamine/phenylpropanolamine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about pheniramine/pyrilamine/phenylpropanolamine?

Phenylpropanolamine, an ingredient in this product, has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food and Drug Administration (FDA) recommends that consumers not use any products that contain phenylpropanolamine.

Pheniramine/pyrilamine/phenylpropanolamine may cause dizziness or drowsiness. Avoid climbing and other hazardous activities while taking this medication. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking pheniramine/pyrilamine/phenylpropanolamine.

Do not take more of this medication than is recommended. If your symptoms do not improve, or if they worsen, talk to your doctor.

Who should not take pheniramine/pyrilamine/phenylpropanolamine?

Do not take pheniramine/pyrilamine/phenylpropanolamine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Before taking this medication, tell your doctor if you have

• kidney disease,


• liver disease,


• 
  

  diabetes,

  
  


• 
  

  glaucoma,

  
  


• 
  

  any type of heart disease or high blood pressure,

  
  


• 
  

  thyroid disease,

  
  


• 
  

  emphysema or chronic bronchitis, or

  
  


• 
  

  difficulty urinating or have an enlarged prostate.

  
  

You may not be able to take pheniramine/pyrilamine/phenylpropanolamine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Pheniramine/pyrilamine/phenylpropanolamine is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. This medication passes into breast milk and may harm a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby. If you are over 65 years of age, you may be more likely to experience side effects from pheniramine/pyrilamine/phenylpropanolamine. You may require a lower dose of this medication. Read the package label for directions or consult your doctor or pharmacist before treating a child with this medication. Children are more susceptible than adults to the effects of medicines and may have unusual reactions.

How should I take pheniramine/pyrilamine/phenylpropanolamine?

Take pheniramine/pyrilamine/phenylpropanolamine exactly as directed. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Do not crush, chew, or break the long-acting or sustained-release forms of this medication. Swallow them whole. If you are unsure of the formulation of the medicine, ask your pharmacist for help. If you cannot swallow the tablets or capsules, look for a liquid form of the medication.

To ensure that you get a correct dose, measure the liquid forms of pheniramine/pyrilamine/phenylpropanolamine with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Do not take more of this medication than is recommended. An overdose of this medication can cause serious harm.

Do not take pheniramine/pyrilamine/phenylpropanolamine for longer than 7 days in a row. If your symptoms do not improve, if they get worse, or if you have a fever, talk to your doctor.

Store pheniramine/pyrilamine/phenylpropanolamine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a pheniramine/pyrilamine/phenylpropanolamine overdose include a dry mouth, large pupils, flushing, nausea, and vomiting.

What should I avoid while taking pheniramine/pyrilamine/ phenylpropanolamine?

Pheniramine/pyrilamine/phenylpropanolamine may cause dizziness or drowsiness. Avoid climbing and other hazardous activities while taking this medication. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking pheniramine/pyrilamine/phenylpropanolamine.

Pheniramine/pyrilamine/phenylpropanolamine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if pheniramine/pyrilamine/phenylpropanolamine is taken with any of these medications.

Pheniramine/ pyrilamine/phenylpropanolamine side effects

Serious side effects are unlikely to occur. Stop taking pheniramine/pyrilamine/ phenylpropanolamine and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Other, less serious side effects may be more likely to occur. Continue to take pheniramine/pyrilamine/phenylpropanolamine and talk to your doctor or try another similar medication if you experience

• 
  

  dryness of the eyes, nose, and mouth;

  
  


• 
  

  drowsiness or dizziness;

  
  


• 
  

  blurred vision;

  
  


• 
  

  difficulty urinating; or

  
  


• 
  

  excitation in children.

  
  

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect pheniramine/ pyrilamine/phenylpropanolamine?

Do not take pheniramine/pyrilamine/phenylpropanolamine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Do not take other over-the-counter cough, cold, allergy, diet, or sleep aids while taking pheniramine/pyrilamine/phenylpropanolamine without first talking to your doctor or pharmacist. Other medications may also contain pheniramine, pyrilamine phenylpropanolamine, or other similar drugs. You may accidentally take too much of these medicines.

Pheniramine/pyrilamine/phenylpropanolamine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if pheniramine/pyrilamine/phenylpropanolamine is taken with any of these medications.

Drugs other than those listed here may also interact with pheniramine/pyrilamine/phenylpropanolamine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

More pheniramine/pyrilamine/phenylpropanolamine resources

• Pheniramine/pyrilamine/phenylpropanolamine Drug Interactions
• Pheniramine/pyrilamine/phenylpropanolamine Support Group
• 0 Reviews for Pheniramine/pyrilamine/phenylpropanolamine - Add your own review/rating

Compare pheniramine/pyrilamine/phenylpropanolamine with other medications

• Allergies
• Eye Redness/Itching
• Hay Fever
• Nasal Congestion
• Pruritus
• Sinusitis
• Upper Respiratory Tract Infection

Where can I get more information?

• Your pharmacist has additional information about pheniramine/pyrilamine/phenylpropanolamine written for health professionals that you may read.

What does my medication look like?

Pheniramine/pyrilamine/phenylpropanolamine is available over the counter under the brand name Triaminic Oral Infant Drops. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Phendiet-105

Generic Name: phendimetrazine (Oral route)

fen-dye-MET-ra-zeen TAR-trate

Commonly used brand name(s)

In the U.S.

• Bontril


• Bontril PDM


• Bontril Slow-Release


• Melfiat


• Obezine


• Phendiet


• Phendiet-105


• Prelu-2

Available Dosage Forms:

• Tablet


• Capsule


• Capsule, Extended Release

Therapeutic Class: Appetite Suppressant, Centrally Acting

Chemical Class: Phendimetrazine

Uses For Phendiet-105

Phendimetrazine is used as part of a short-term plan, along with a low calorie diet, for weight reduction. It is used in obese patients who have not been able to lose weight with diet and exercise alone. Phendimetrazine belongs to the group of medicines known as appetite suppressants.

This medicine is available only with your doctor's prescription.

Before Using Phendiet-105

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of phendimetrazine tablets in the pediatric population. Safety and efficacy have not been established.

Use of phendimetrazine slow-release capsules is not recommended in children younger than 12 years of age.

Geriatric

No information is available on the relationship of age to the effects of phendimetrazine in geriatric patients.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Brofaromine


• Clorgyline


• Furazolidone


• Iproniazid


• Isocarboxazid


• Lazabemide


• Linezolid


• Moclobemide


• Nialamide


• Pargyline


• Phenelzine


• Procarbazine


• Rasagiline


• Selegiline


• Sibutramine


• Toloxatone


• Tranylcypromine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Agitated state or


• Arteriosclerosis (hardening of the arteries), advanced or


• Drug abuse or dependence, history of or


• Glaucoma or


• Heart problems (e.g., heart murmur, valvular heart disease) or


• Hypertension (high blood pressure), moderate to severe or


• Hyperthyroidism (overactive thyroid)—Should not be used in patients with these conditions.

• Hypertension (high blood pressure), mild—Use with caution. May make these conditions worse.

Proper Use of phendimetrazine

This section provides information on the proper use of a number of products that contain phendimetrazine. It may not be specific to Phendiet-105. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much is taken, it may become habit-forming (causing mental or physical dependence).

This medicine is available in two forms: slow-release capsules and tablets. Ask your doctor which dosage form is right for you.

Carefully follow your doctor's instructions for a reduced-calorie diet plan and regular exercise. Talk with your doctor before starting any exercise program.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For treatment of obesity:
  
  • For oral dosage form (slow-release capsules):
    
    • Adults and teenagers—One capsule or 105 milligrams (mg) once a day, taken 30 to 60 minutes before the morning meal.
    
    
    • Children younger than 12 years of age—Use is not recommended.
    
    
  
  
  • For oral dosage form (tablets):
    
    • Adults—One tablet or 35 milligrams (mg) two or three times a day, taken one hour before meals. Your doctor may adjust your dose as needed. However, the dose is usually not more than 2 tablets three times a day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Phendiet-105

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and does not cause any unwanted effects.

Do not use phendimetrazine if you are also using similar medicines such as benzphetamine, diethylpropion, mazindol, phentermine, Didrex®, or Suprenza™. Also, do not use this medicine if you have used an MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil®, or Parnate® within the past 14 days. Using these medicines together may cause serious unwanted effects.

Make sure your doctor knows if you are pregnant or planning to become pregnant before using this medicine.

This medicine may be habit-forming. If you think this medicine is not working properly after you have taken it for a few weeks, do not increase the dose. Instead, check with your doctor.

Stop using this medicine and check with your doctor right away if you notice a decrease in your ability to exercise, if you faint, or if you have chest pain, swelling of your feet or lower legs, or trouble with breathing. These may be symptoms of a very serious heart or lung problem.

This medicine may cause some people to become dizzy, lightheaded, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

For diabetic patients: This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests or if you have any questions, check with your doctor.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription and nonprescription (over-the-counter) medicines, dietary supplements, herbal remedies, or medicines for appetite control, asthma, colds, cough, hay fever, and sinus problems.

Phendiet-105 Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

• Seeing, hearing, or feeling things that are not there


• severe mental changes

Incidence not known

• Anxiety


• burning while urinating


• difficult or painful urination


• dizziness


• dry mouth


• fast, irregular, pounding, or racing heartbeat or pulse


• feeling of warmth


• headache


• hyperventilation


• increased need to urinate


• irritability


• nervousness


• numbness or tingling in the arms or legs


• passing urine more often


• redness of the face, neck, arms, and occasionally, upper chest


• restlessness


• shakiness in the legs, arms, hands, or feet


• shortness of breath


• sweating


• trembling or shaking of the hands or feet


• trouble sleeping


• trouble thinking, speaking, or walking


• weakness

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Abdominal or stomach cramps


• blurred vision


• change in consciousness


• convulsions


• diarrhea


• discouragement


• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position


• fainting


• fast, slow, or irregular heartbeat


• feeling sad or empty


• lack of appetite


• lightheadedness


• loss of consciousness


• loss of interest or pleasure


• nausea


• overactive reflexes


• panic


• physical attempt to injure


• pounding in the ears


• rapid breathing


• sweating


• tiredness


• trouble concentrating


• unusual tiredness or weakness


• violent actions


• vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Decreased interest in sexual intercourse


• difficulty having a bowel movement (stool)


• inability to have or keep an erection


• increased in sexual ability, desire, drive, or performance


• increased interest in sexual intercourse


• loss in sexual ability, desire, drive, or performance


• sleeplessness


• stomach pain


• unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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Pegasys

Generic Name: peginterferon alfa-2a (peg in ter FEER on AL fa 2 a)

Brand Names: Pegasys, Pegasys ProClick Autoinjector

What is peginterferon alfa-2a?

Peginterferon alfa-2a is made from human proteins that help the body fight viral infections.

Peginterferon alfa-2a is used to treat chronic hepatitis B or C. Peginterferon alfa-2a is often used together with another medication called ribavirin (Copegus, Rebetol, RibaPak, Ribasphere, RibaTab).

Peginterferon alfa-2a may also be used for purposes not listed in this medication guide.

What is the most important information I should know about peginterferon alfa-2a?

Peginterferon alfa-2a is often used together with another medication called ribavirin. Ribavirin is known to cause birth defects or death in an unborn baby. If a man fathers a child while using ribavirin, the baby may have birth defects. You should not use this medication if you are allergic to peginterferon alfa-2a, or if you have autoimmune hepatitis, liver failure, or a hemoglobin blood cell disorder such as sickle-cell anemia or thalassemia, if you are pregnant, or if you are a man and your sexual partner is pregnant.

Before using this medication, tell your doctor about all of your medical conditions. Also tell your doctor if you have ever had a drug or alcohol addiction, or depression, mental illness, or suicidal thoughts.

Using this medication will not prevent you from passing hepatitis.

What should I discuss with my healthcare provider before using peginterferon alfa-2a?

You should not use this medication if you are allergic to peginterferon alfa-2a, or if you have:

• 
  

  liver failure or autoimmune hepatitis;

  
  


• 
  

  a hemoglobin blood cell disorder such as sickle-cell anemia or thalassemia;

  
  


• 
  

  if you are pregnant; or

  
  


• 
  

  if you are a man and your sexual partner is pregnant.

  
  

To make sure you can safely use peginterferon alfa-2a, tell your doctor if you have any of these other conditions:

• 
  

  anemia (a lack of red blood cells);

  
  


• liver problems other than hepatitis;


• kidney disease (or if you are on dialysis);


• 
  

  HIV or AIDS;

  
  


• 
  

  diabetes;

  
  


• 
  

  a thyroid disorder;

  
  


• 
  

  lung disease;

  
  


• 
  

  a bleeding or blood clotting disorder;

  
  


• 
  

  heart disease or prior heart attack;

  
  


• 
  

  eye problems;

  
  


• 
  

  problems with your sleep;

  
  


• 
  

  colitis, or a history of stomach or intestinal bleeding;

  
  


• 
  

  an autoimmune disorder such as rheumatoid arthritis, systemic lupus erythematosus (SLE), or psoriasis;

  
  


• 
  

  a history of cancer;

  
  


• 
  

  history of liver or other organ transplant;

  
  


• 
  

  history of depression, anxiety, mental illness, suicidal thoughts, or drug or alcohol addiction;

  
  


• 
  

  if you have both hepatitis B and hepatitis C; or

  
  


• 
  

  if you have used interferon alfa in the past and it was not effective.

  
  

Peginterferon alfa-2a is often used together with another medication called ribavirin. Ribavirin is known to cause birth defects or death in an unborn baby. You may need to have a negative pregnancy test before taking these two medications together.

• 
  

  If you are a woman, do not use peginterferon alfa-2a and ribavirin if you are pregnant.

  
  


• 
  

  If you are a man, do not use peginterferon alfa-2a and ribavirin if your sexual partner is pregnant. An unborn baby could also be harmed if a man fathers the child while he is taking ribavirin.

  
  


• 
  

  Use at least 2 effective forms of birth control while either sexual partner is using peginterferon alfa-2a with ribavirin. Keep using 2 forms of birth control for at least 6 months after treatment ends.

  
  


• 
  

  Tell your doctor right away if a pregnancy occurs while either the mother or the father is using peginterferon alfa-2a together with ribavirin.

  
  

It is not known whether peginterferon alfa-2a passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medication.

How should I use peginterferon alfa-2a?

Peginterferon alfa-2a is injected under the skin. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

Peginterferon alfa-2a is usually given once per week, on the same day each week at about the same time of day. Your doctor may occasionally change your dose to make sure you get the best results.

Do not shake the medication bottle or you may ruin the medicine. Prepare your dose in a syringe only when you are ready to give yourself an injection. Do not use the medication if it has changed colors or has particles in it. Call your doctor for a new prescription.

Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Peginterferon alfa-2a can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often. Visit your doctor regularly.

If you have hepatitis B you may develop liver symptoms while you are using peginterferon alfa-2a, and even after you stop using this medication. Your doctor may want to check your liver function more often if this happens.

If your doctor changes your brand, strength, or type of peginterferon alfa-2a, your dosage needs may change. Ask your pharmacist if you have any questions about the new kind of peginterferon alfa-2a you receive at the pharmacy.

Hepatitis is sometimes treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with hepatitis should remain under the care of a doctor.

Store in the refrigerator, protected from light. Do not freeze.

What happens if I miss a dose?

Use the medicine as soon as you remember the missed dose, then go back to your regular schedule on the day your next dose is due. If you are more than 2 days late in using your injection, call your doctor for instructions. Do not use extra medicine to make up a missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using peginterferon alfa-2a?

Avoid drinking alcohol. It may increase your risk of liver damage. This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Using this medication will not prevent you from passing hepatitis. Follow your doctor's instructions about how to prevent passing the disease to another person.

Peginterferon alfa-2a side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

• 
  

  confusion, severe depression, thoughts of hurting yourself or others;

  
  


• 
  

  unusual thoughts or behaviors, feeling anxious or aggressive;

  
  


• 
  

  sudden weakness, loss of balance or coordination, or problems with speech;

  
  


• 
  

  chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

  
  


• 
  

  numbness, burning, pain, or tingly feeling;

  
  


• 
  

  fever, chills, body aches, flu symptoms;

  
  


• 
  

  easy bruising or bleeding, feeling very tired;

  
  


• 
  

  sores in your mouth, nose or eyes;

  
  


• 
  

  redness, crusting, or drainage in your eyes;

  
  


• 
  

  worsening of psoriasis;

  
  


• 
  

  cough, stabbing chest pain, feeling short of breath;

  
  


• 
  

  severe pain in your upper stomach spreading to your back, fast heart rate;

  
  


• 
  

  high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss);

  
  


• 
  

  low blood sugar (headache, hunger, weakness, sweating, tremors, irritability, trouble concentrating);

  
  


• 
  

  vision changes, headache or pain behind your eyes; or

  
  


• 
  

  fever with severe stomach pain and bloody diarrhea.

  
  

Less serious side effects may include:

• 
  

  vomiting, upset stomach, loss of appetite, mild diarrhea;

  
  


• 
  

  weight changes, feeling very hot or cold;

  
  


• 
  

  headache, muscle or joint pain;

  
  


• 
  

  sleep problems (insomnia);

  
  


• 
  

  temporary hair loss, mild skin rash; or

  
  


• 
  

  itching, redness, dryness, or swelling where the medicine was injected.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect peginterferon alfa-2a?

Tell your doctor about all other medicines you use, especially:

• 
  

  azathioprine (Azasan, Imuran);

  
  


• 
  

  telbivudine (Tyzeka);

  
  


• 
  

  theophylline (Slo-Bid, Theobid, Theo-Dur, and others);

  
  


• 
  

  methadone (Diskets, Dolophine, Methadose); or

  
  


• 
  

  HIV or AIDS medication such as abacavir (Ziagen), didanosine (Videx), emtricitabine (Atripla, Emtriva, Truvada), lamivudine (Epivir, Combivir), stavudine (Zerit), tenofovir (Viread), zalcitabine (Hivid), or zidovudine (Retrovir).

  
  

This list is not complete and other drugs may interact with peginterferon alfa-2a. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Pegasys resources

• Pegasys Side Effects (in more detail)
• Pegasys Use in Pregnancy & Breastfeeding
• Pegasys Drug Interactions
• Pegasys Support Group
• 6 Reviews for Pegasys - Add your own review/rating

• Pegasys Prescribing Information (FDA)


• Pegasys Consumer Overview


• Pegasys Advanced Consumer (Micromedex) - Includes Dosage Information


• Pegasys MedFacts Consumer Leaflet (Wolters Kluwer)


• Peginterferon Alfa-2a Professional Patient Advice (Wolters Kluwer)

Compare Pegasys with other medications

• Hepatitis B
• Hepatitis C

Where can I get more information?

• Your pharmacist can provide more information about peginterferon alfa-2a.

See also: Pegasys side effects (in more detail)